我国儿童精神药物使用现状分析

张鑫炎, 胡晓雯, 赵宇璇, 聂小燕, 史录文

中国药学杂志 ›› 2023, Vol. 58 ›› Issue (10) : 933-938.

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中国药学杂志
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中国药学杂志 ›› 2023, Vol. 58 ›› Issue (10) : 933-938. DOI: 10.11669/cpj.2023.10.010
论著

我国儿童精神药物使用现状分析

  • 张鑫炎1, 胡晓雯1, 赵宇璇1, 聂小燕1,2*, 史录文1,2
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Analysis of the Current Situation of Psychotropic Drug Use among Children in China

  • ZHANG Xin-yan1, HU Xiao-wen1, ZHAO Yu-xuan1, NIE Xiao-yan1,2*, SHI Lu-wen1,2
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摘要

目的 了解中国儿童使用精神药物的用药率及用药模式,为促进儿童合理使用精神药物提供参考。方法 基于全国基本医疗保险参保人员医疗服务利用情况抽样调查数据库,采用横截面研究分析中国儿童精神药物用药率、用药模式及多重用药情况。结果 数据库共纳入参保儿童757 639人,其中 11 898例儿童使用了至少一种精神药物,精神药物用药率为15.7‰。各类精神药物中,镇静催眠药的用药率最高(11.8‰),其次是抗焦虑药(3.0‰),抗精神病药(1.6‰),抗抑郁药(0.6‰)和情绪稳定剂(0.1‰)用药率较低。其中,奥氮平(16.2%)、舍曲林(45.6%)、咪达唑仑(76.9%)、坦度螺酮(63.4%)、及碳酸锂(100.0%)分别在各类精神药物用药人群中使用频率最高。对上述的11 898位用药儿童中精神药物多重用药情况分析可得,儿童中精神药物多重用药率为19.5%。结论 本研究表明,我国儿童人群中精神障碍需要关注。同时应加强儿童用药动态监测和评估体系,改善临床实践中可能出现的治疗不足和药物使用不当的情况。

Abstract

OBJECTIVE To investigate the prevalence and use patterns of psychotropic drugs in Chinese children and provide a reference for promoting the rational use of psychotropic drugs in children. METHODS Based on the national survey on the medical service utilization of basic medical insurance beneficiaries, a cross-sectional study was conducted to analyze the prevalence, drug utilization patterns, and polypharmacy among children in China. RESULTS The database included 757639 insured children, among whom 11898 were observed with at least one psychotropic drug use record in the database. The prevalence of psychotropic drug use was 15.7‰. Among different psychotropic classes, the prevalence of sedative-hypnotic drugs was the highest (11.8‰), followed by anxiolytics (3.0‰), antipsychotics (1.6‰), antidepressants (0.6‰) and mood stabilizers (0.1‰). Among them, olanzapine (16.2%), sertraline (45.6%), midazolam (76.9%), tandospirone (63.4%) and lithium (100.0%) were the most commonly used drugs in each psychotropic class, respectively. Among the 11898 children, 19.5% received psychotropic polypharmacy treatment. CONCLUSION This study shows that mental disorders among Chinese children need attention. The dynamic monitoring and evaluation system of drugs in children should be strengthened to improve the under-treatment and inappropriate medication in clinical practice.

关键词

合理用药 / 儿童 / 抗抑郁药 / 镇静催眠药 / 抗精神病药

Key words

rational use of drugs / children / antidepressants / sedative-hypnotics / antipsychotics

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张鑫炎, 胡晓雯, 赵宇璇, 聂小燕, 史录文. 我国儿童精神药物使用现状分析[J]. 中国药学杂志, 2023, 58(10): 933-938 https://doi.org/10.11669/cpj.2023.10.010
ZHANG Xin-yan, HU Xiao-wen, ZHAO Yu-xuan, NIE Xiao-yan, SHI Lu-wen. Analysis of the Current Situation of Psychotropic Drug Use among Children in China[J]. Chinese Pharmaceutical Journal, 2023, 58(10): 933-938 https://doi.org/10.11669/cpj.2023.10.010
中图分类号： R95   

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国家自然科学基金项目资助(81803497)
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